Diagnosis of Coxiella burnetii endocarditis by using nanopore targeted sequencing: a case report.

ABSTRACT:

Background

Infective endocarditis (IE) can be caused by a variety of pathogens, including bacteria, fungi, and atypical pathogens. The diversity of IE manifestations contributes to diagnostic uncertainty, which can lead to missed diagnoses and inappropriate treatment. Diagnosing Coxiella burnetii endocarditis is particularly challenging, as routine blood cultures often yield negative results and echocardiography seldom reveals vegetations. In recent years, the rapid development of sequencing technology provides a new direction for the diagnosis of IE.

Case presentation

The present study reports the case of a 57-year-old male patient who was admitted with a diagnosis of severe aortic stenosis. Cardiac computed tomography (CT) angiography revealed a diastolic aortic valve malf

SUBMITTER: Yan X 

PROVIDER: S-EPMC11800518 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature