Postoperative sepsis and its sequential impact on dementia.

ABSTRACT:

Background

Postoperative sepsis is a severe complication associated with increased mortality and potential long-term cognitive decline, including dementia. However, the relationship between postoperative sepsis and dementia remains poorly understood.

Methods

This retrospective cohort study used data from the National Database in Taiwan, covering the period from January 1, 2005, to December 31, 2022. The index period for surgeries was set between January 1, 2008, and December 31, 2013, allowing the identification of patients without prior dementia. A landmark period of 12 months following surgery was defined to capture the number of postoperative sepsis events, which were then analyzed for their impact on dementia risk. After 1:4 propensity score matching (PSM), dementia and

SUBMITTER: Sun M 

PROVIDER: S-EPMC11800527 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature