Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds.

ABSTRACT: Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. The bioadhesives are fabricated from the aggregation of LA, MXene and Ag⁺ through their supramolecular interactions, which can be rapidly formed in mild environments, showing strong interface adhesion without adhesive failure caused by depolymerization, while exhibiting mechanical self-reinforcing. To further improve the adhesive strength, the formation of MXene/Ag⁺/LA interactions was integrated into

SUBMITTER: Lei R 

PROVIDER: S-EPMC11800535 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature