A case report of confirmed difficult pulmonary tuberculosis based on the hybrid capture-based tNGS method.

ABSTRACT:

Background

Early diagnosis of pulmonary tuberculosis can greatly reduce the harm caused by the disease. However, traditional diagnostic methods have various shortcomings in diagnosing pulmonary tuberculosis. Currently, with the increasing popularity, iteration, and decreasing costs of Next-generation sequencing (NGS) testing technology, NGS is being more widely applied in the diagnosis of pulmonary tuberculosis.

Case presentation

A 29-year-old male presented with "fever accompanied by cough for more than 20 days." Multiple chest CT scans revealed progressive enlargement of the right hilar lymph nodes and thickening of the interlobular septa in the right upper lobe. Routine testing of bronchoalveolar lavage fluid, search for tuberculosis bacilli, bacterial and fungal cultures

SUBMITTER: Chen W 

PROVIDER: S-EPMC11800540 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature