Burden of HPV-induced diseases and cost effectiveness of catch-up vaccination in Czech Republic: a model-based study.

ABSTRACT:

Objectives

Human papillomavirus (HPV) infections are highly prevalent sexually transmitted infections, notably associated with various cancers. This study analyses the health and economic impacts of HPV-associated diseases in the Czech Republic and evaluates the cost-effectiveness of a catch-up vaccination program.

Methods

Utilizing a Markov multistate model, the study assesses the lifetime impacts and costs related to HPV infections. Cohorts of ages 15-21 were simulated to assess the impact of catch-up vaccination outside the 11-year-old age group.

Results

The total quality-adjusted life years (QALYs) for the female and male cohorts (together 119,362 individuals) were higher in the vaccination scenario compared to the non-vaccination scenario. The increase in QALYs w

SUBMITTER: Kamensky V 

PROVIDER: S-EPMC11800564 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature