Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes.

ABSTRACT:

Background

Olfactory receptor (OR) genes are highly polymorphic and form extensive families that recognize a wide range of vertebrate odorants. To explore the genetic diversity of MHC-linked OR genes and their connection to MHC genes, we conducted a combined haplotype analysis of MHC-linked OR and MHC class I genes to determine the influence of MHC on OR diversity, which could be associated with MHC-based mate selection.

Results

We selected nine MHC-linked OR genes based on their expression levels in pig testes and developed a sequence-based typing method for these genes. We then performed high-resolution typing of these OR genes, along with three major classical MHC class I genes (SLA-1, -2, and - 3), in 48 pigs across six breeds. We observed significantly higher allelic di

SUBMITTER: Kang M 

PROVIDER: S-EPMC11800647 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature