Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM_2.5 polygenic risk score study.

ABSTRACT:

Rationale

Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap.

Objectives

To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma.

Methods

We complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM_2.5. This PRS was validated using internal data and data from the All of Us cohort.

Measurements and results

We included 6023 patients in the GWAS, restricted to the African ancestry coh

SUBMITTER: Kelchtermans J 

PROVIDER: S-EPMC11800831 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature