Loss of ARID1A expression is associated with systemic inflammation markers and has important prognostic significance in gastric cancer.

ABSTRACT:

Background

The tumor suppressor gene AT-rich interactive domain 1A (ARID1A) and systemic inflammatory response (SIR) have been reported to be related to the sensitivity to immunotherapy. This study intended to explore the relationship between ARID1A expression and SIR, and to further elucidate the prognostic value of ARID1A expression in gastric cancer (GC).

Methods

The mRNA and protein expression of ARID1A were detected in 272 formalin-fixed paraffin-embedded (FFPE) tumor tissues. The data of nine systemic inflammation markers were collected 1 week before gastrectomy. Univariate and multivariate COX analysis were used to screen out independent predictors of GC.

Results

Negative expression of ARID1A protein was related to GC with deficient mismatch repair (dMMR) (p = 

SUBMITTER: Wang X 

PROVIDER: S-EPMC11801042 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature