Trophoblast cell-surface antigen 2 expression in lung cancer patients and the effects of anti-cancer treatments.

ABSTRACT:

Background

Trophoblast cell-surface antigen 2 (TROP2) is expressed on the surface of trophoblast cells and many malignant tumor cells. However, data on TROP2 expression in advanced lung cancer are insufficient, and its changes have not been fully evaluated.

Methods

We assessed the prevalence and changes in TROP2 expression in patients with lung cancer who received anti-cancer treatments using immunohistochemical (IHC) analysis with an anti-TROP2 antibody (clone: SP295). IHC scores were graded from 0 to 3; grade ≥ 2 was considered positive for TROP2 expression. We defined a difference in IHC score, before and after anti-cancer treatments, as the change in TROP2 expression.

Results

Before anti-cancer treatment, TROP2 expression was observed in 89% (143/160) of the patie

SUBMITTER: Omori S 

PROVIDER: S-EPMC11801068 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature