Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction.

ABSTRACT: Skeletal muscles are essential for locomotion, posture, and metabolic regulation. To understand physiological processes, exercise adaptation, and muscle-related disorders, it is critical to understand the molecular pathways that underlie skeletal muscle function. The process of muscle contraction, orchestrated by a complex interplay of molecular events, is at the core of skeletal muscle function. Muscle contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular junction. Within muscle fibers, calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate force. Regulation of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction coupling. The development and gr

SUBMITTER: Hashemolhosseini S 

PROVIDER: S-EPMC11801303 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature