Use of alpha-adrenergic antagonists for lower urinary tract symptoms is not associated with worsening cognitive function.

ABSTRACT:

Introduction

Alpha-adrenergic antagonists are widely prescribed for lower urinary tract symptoms (LUTS), however there has been a report that their use is associated with dementia. Our objective was to investigate if new users of alpha-adrenergic antagonists with varying levels of cognitive impairment had an increased risk of cognitive decline compared to non-users.

Methods

This was a retrospective cohort study, utilizing data from the National Alzheimer's Coordinating Center (NACC) data set. After applying relevant exclusion criteria, 916 people who were newly using alpha-antagonist medications were matched with a propensity score to 916 who were not using these medications. The primary outcome was a clinically relevant cognitive decline measured by the Clinical Dementia Ra

SUBMITTER: Berto FG 

PROVIDER: S-EPMC11801311 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature