Drug-Induced Liver Injury Caused by Metamizole: Identification of a Characteristic Injury Pattern.

ABSTRACT:

Background and aims

Drug-induced liver injury (DILI) due to metamizole has gained increasing attention. Causality assessment remains a challenge, especially in patients with co-medications. We therefore aimed to further characterise metamizole DILI cases.

Methods

The data of patients with metamizole intake from our prospective study on acute liver injury with potential drug-related causes were analysed. Diagnosis and causality assessment were based on a thorough work-up and long-term follow-up.

Results

DILI was associated with metamizole in 61 of 324 DILI patients (prevalence 18.8%). A highly characteristic clinical pattern was observed in 43 of the 61 patients, characterised by marked elevation of transaminases peaking at the time of DILI recognition and a more prono

SUBMITTER: Weber S 

PROVIDER: S-EPMC11801327 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature