Debut of enzyme-responsive anionic cyanine for overlap-free NIR-II-to-I dual-channel tumour imaging.

ABSTRACT: Bridging the disparity between traditional surgical resection imaging and ex vivo histopathology, fluorescence imaging is considered a promising tool in disease diagnosis and imaging navigation. Nevertheless, its usefulness is undermined by the variability of single-wavelength fluorescence signals and limited penetration of NIR-I (650-900 nm) bioimaging. In this work, we present a novel NIR-II ratiometric fluorescent probe (CFC-GSH) with γ-glutamyl transpeptidase (GGT) sensitivity for multifunctional bioimaging. This probe leverages a GSH-capped anionic cyanine, with advantages of high brightness, excellent photostability, high specificity and favourable biocompatibility. CFC-GSH exhibits an intrinsically stable NIR-II signal prior to triggering, which can be utilized for in vivo

SUBMITTER: Chu F 

PROVIDER: S-EPMC11801379 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature