Host-guest chemistry on living cells enabling recyclable photobiocatalytic cascade.

ABSTRACT: Combining chemical and whole-cell catalysts enables sustainable chemoenzymatic cascade reactions. However, their traditional combination faces challenges in catalyst recycling and maintaining cell viability. Here, we introduce a supramolecular host-guest strategy that efficiently attaches photocatalysts to bacterial cells, facilitating recyclable photobiocatalysis. This method involves attaching a cationic polyethylenimine (PEI) polymer, functionalized with β-cyclodextrin (β-CD), to E. coli cells. The polymer attachment is biocompatible and protective, safeguarding the cells from harsh conditions such as UV radiation and organic solvents, without causing cell death. Additionally, the presence of β-CD imparts a plug-and-play capability to the cells, enabling the straightforward integ

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11801380 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature