Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7.

ABSTRACT:

Purpose

The purpose of this study was to evaluate the feasibility and utility of optical coherence tomography (OCT)-based, targeted microperimetry grids in assessing focal lesions in intermediate age-related macular degeneration (iAMD).

Methods

The multicenter, prospective PINNACLE study enrolled 395 patients with iAMD aged 55 to 90 years across 12 international sites. Participants underwent imaging, including OCT and microperimetry, every 4 to 12 months over 3 years. Deep learning algorithms detected focal lesions and changes in OCT images, including drusen regression, EZ/IZ loss with hypertransmission, and subretinal fluid, guiding 5-point microperimetry targeted to lesion locations. Data were analyzed using linear mixed models to estimate differences between retinal sensi

SUBMITTER: Futterknecht S 

PROVIDER: S-EPMC11801386 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature