RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data.

ABSTRACT:

Introduction

The four members of the p90 ribosomal S6 kinase (RSK) family are serine/threonine protein kinases, which are phosphorylated and activated by ERK1/2. RSK1/2/3 are further phosphorylated by PDK1. Receiving inputs from two major signaling pathways places RSK as a key signaling node in numerous pathologies. A plethora of RSK1/2 substrates have been identified, and in the majority of cases the causative roles these RSK substrates play in the pathology are unknown.

Areas covered

The majority of studies have focused on RSK1/2 and their functions in a diverse group of cancers. However, RSK1/2 are known to have important functions in cardiovascular disease and neurobiological disorders. Based on the literature, we identified substrates that are common in these pathologie

SUBMITTER: Spirrison AN 

PROVIDER: S-EPMC11801519 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature