Identification and prioritization of novel therapeutic candidates against glutamate racemase from Klebsiella pneumoniae.

ABSTRACT:

Background

Klebsiella pneumoniae, a gram-negative bacterium in the Enterobacteriaceae family, is non-motile, encapsulated, and a major cause of nosocomial infections, particularly in intensive care units. The bacterium possesses a thick polysaccharide capsule and fimbriae, which contribute to its virulence, resistance to phagocytosis, and attachment to host cells. The bacterium has developed serious resistance to most antibiotics currently in use.

Objective

This study aims to investigate the structural properties of MurI (glutamate racemase) from Klebsiella pneumoniae and to identify potential candidate inhibitors against the protein, which will help in the development of new strategies to combat the infections related to MDR strains of Klebsiella pneumoniae.

Methods

SUBMITTER: Kumar A 

PROVIDER: S-EPMC11801594 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature