Do Antibiotics Cause Inflammatory Bowel Disease? A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), exhibits a multifactorial pathogenesis influenced by genetic and environmental factors. Antibiotic usage has been implicated in modifying the gut microbiome, potentially leading to dysbiosis and contributing to IBD risk. Despite existing literature, the relationship remains inconclusive. This meta-analysis aimed to evaluate the association between prior antibiotic use and the onset of IBD.

Methods

A systematic literature search in PubMed was conducted to identify studies exploring the link between antibiotic use and subsequent IBD diagnosis. Studies reporting CD, UC, or both as primary outcomes were included. The meta-analysis, performed according to PRISMA guideline

SUBMITTER: Scharf E 

PROVIDER: S-EPMC11801854 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature