The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors.

ABSTRACT:

Background

Treatment regimens for patients with metastatic or recurrent post-radiation, locoregional, unresectable salivary cancer are limited. An inverse correlation between somatostatin receptor 2 (SSTR2) and the proliferating marker Ki-67 in neuroendocrine tumors has enabled a treatment plan for metastatic disease, utilizing peptide receptor radionuclide therapy. Interestingly, healthy salivary glands express high levels of SSTR2. In this study, the presence of SSTR2, its correlation with Ki-67 in glandular salivary carcinomas and the clinical applicability thereof was determined.

Methods

In the retrospective part of this study, 76 adequate tumor tissue specimens obtained from patients diagnosed with primary or metastatic salivary carcinomas between 1988 and 2016, were co

SUBMITTER: Meirovitz A 

PROVIDER: S-EPMC11801970 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature