A Trade-Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors in <i>Staphylococcus aureus</i> In Vivo.

ABSTRACT: Antimicrobial peptides (AMPs) are essential immune effectors of multicellular organisms. Bacteria can evolve resistance to AMPs. Surprisingly, when used to challenge the yellow mealworm beetle, Tenebrio molitor, Staphylococcus aureus resistant to an abundant AMP (tenecin 1) of the very same host species did not increase host mortality or bacterial load compared to infections with wild-type S. aureus. A possible explanation is that antimicrobial resistance is costly due to the collaterally increased sensitivity of AMP-resistant strains to other immune effectors. Here, we study the sensitivity of a group of AMP-resistant S. aureus strains (resistant to tenecin 1 or a combination of tenecin 1 + 2) to other immune effectors such as phenoloxidase and other AMPs in vi

SUBMITTER: El Shazely B 

PROVIDER: S-EPMC11802329 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature