Circulating PIWI-interacting RNAs in Acute Ischemic Stroke patients.

ABSTRACT:

Background

Stroke refers to an abrupt neurological deficit, caused by an acute focal injury of the central nervous system via infarction or hemorrhage due to impaired vascularity, and remains among the leading causes of disability and death worldwide. Stroke is often preceded by an episode of neuronal deficit termed transient ischemic attack (TIA), which presents an effective opportunity for mitigating the risk of an eminent acute ischemic stroke (AIS). Circulating non-coding RNAs (ncRNAs) have emerged as important biomarkers for stroke, but PIWI-interacting RNAs (piRNAs), a class of small regulatory ncRNAs, have not been previously explored as diagnostic or prognostic biomarkers for stroke.

Methods

We conducted comprehensive circulating piRNA profiling of AIS and TIA patien

SUBMITTER: Toor SM 

PROVIDER: S-EPMC11802372 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature