Selective activity of Tabebuia avellanedae against Giardia duodenalis infecting organoid-derived human gastrointestinal epithelia.

ABSTRACT: Giardia duodenalis is a widespread intestinal protozoan that affects mammals, including humans. Symptoms can range from being subclinical to causing severe abdominal pain and diarrhoea. Giardiasis often requires repeated treatment with synthetic drugs like metronidazole. In recent years, treatment failures in clinical cases involving nitroimidazoles have been increasingly reported. Consequently, identifying therapeutic alternatives is necessary. Medicinal plants have traditionally been used as antiparasitic compounds, but systematic evaluation under controlled experimental conditions is often lacking. Here, we evaluated the in vitro efficacy of Tabebuia avellanedae dry and hydroalcoholic extracts, as well as one of its active compounds, β-lapachone, as potential treatment against G. duoden

SUBMITTER: Rigamonti G 

PROVIDER: S-EPMC11802375 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature