The mediating role of body surface area-adjusted basal metabolic rate: effects of low muscle mass and central obesity on cognitive impairment in Chinese patients with type 2 diabetes mellitus.

ABSTRACT:

Background

This study investigates the relationship between basal metabolic rate (BMR), body composition, obesity indices, and cognitive impairment (CI) in middle-aged and older type 2 diabetes mellitus (T2DM) patients, assessing their potential role in CI screening.

Methods

A cross-sectional study included 1243 T2DM patients over 45 years old. CI was assessed using the Montreal Cognitive Assessment. BMR and body composition indices were measured through bioelectrical impedance analysis. The associations and predictions related to CI were explored using multivariable-adjusted logistic regression, restricted cubic spline (RCS) models, and receiver operating characteristic (ROC) curve analyses. Mediation analysis explored the role of BMR adjusted by body surface area (BMR/BSA)

SUBMITTER: Zhai YJ 

PROVIDER: S-EPMC11802378 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature