Endothelial autophagy-related gene 7 contributes to high fat diet-induced obesity.

ABSTRACT:

Objective

Obesity-associated metabolic dysfunction is a major public health concern worldwide. Endothelial dysfunction is a hallmark of metabolic dysfunction, and endothelial cells affect metabolic functions. Because autophagy-related gene 7 (ATG7) is involved in various cellular physiology, we investigated the roles of endothelial cell-ATG7 (EC-ATG7) on high-fat diet-induced obesity and its related metabolic dysfunction.

Methods

We generated an endothelial-specific Atg7 knock-out mouse by breeding Atg7^flox/flox mouse with the Chd5-Cre mouse, and investigated the metabolic phenotypes associated with high-fat diet (HFD)-induced obesity. Body weight, food intake, glucose tolerance, insulin sensitivity, and liver fat accumulation were measured in endothelial Atg7 def

SUBMITTER: Ren G 

PROVIDER: S-EPMC11802379 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature