Mapping hippocampal glutamate in healthy aging with <i>in vivo</i> glutamate-weighted CEST (GluCEST) imaging.

ABSTRACT:

Introduction

Hippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in healthy old (HOA) and young (HYA) adults.

Methods

Bilateral hippocampal GluCEST data was acquired from 27 HOA and 22 HYA using 7T MRI. GluCEST differences by age and hemisphere were tested with a linear mixed model. GluCEST asymmetry index was also evaluated by age. Exploratory analyses examined associations between hippocampal GluCEST, age group, and scores on the Montreal Cognitive Assessment (MoCA) and Cognitive Complaints Index (CCI).

Results

GluCEST levels showed an ag

SUBMITTER: Pecsok MK 

PROVIDER: S-EPMC11802501 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature