Immune checkpoint inhibitor-induced diabetes mellitus: clinical characteristics and risk factors.

ABSTRACT:

Background

Emerging evidence indicates that immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) might be more common than initially reported, and more different clinical pictures associated with ICI-DM were described.

Objective

The aim of our study was to identify the clinical characteristics and possible predictive factors of ICI-DM.

Methods

We conducted a retrospective review of patients who received immune checkpoint inhibitors (ICI) at West China Hospital, Sichuan University until June 2023. Patients were reviewed at death or on 7 May 2024. We applied logistic regression to study the associations between clinical characteristics and ICI-DM.

Results

Our study included 8,199 participants who received ICI between October 2014 and June 2023. Among th

SUBMITTER: Zhan M 

PROVIDER: S-EPMC11802519 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature