Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics.

ABSTRACT:

Background

The convergence of macrophage-targeted strategies with immune checkpoint blockade therapies defines a pivotal avenue in contemporary tumor therapy. Identifying robust genetic regulators in this context is imperative.

Methods

This study elucidates IFI30's role in enhancing Major Histocompatibility Complex II (MHC-II) restriction antigen processing. Despite its recognition in cancer immunotherapy, IFI30 remains a nascent focus. Our approach involves a multi-omics analysis of IFI30 tumor immunological profile in the macrophage-mediated Tumor Microenvironment (TME), spanning various cancers and bolstered by rigorous co-culture laboratory work.

Results

IFI30 predominantly localizes in monocyte/macrophage populations, correlating strongly with immune cell infiltr

SUBMITTER: Jiang L 

PROVIDER: S-EPMC11802554 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature