Exhaustion of CD8^pos central memory regulatory T cell differentiation is involved in renal allograft rejection.

ABSTRACT:

Background

The role of regulatory CD8^pos T cells (CD8^pos Tregs) and cytotoxic CD8^pos responder T cells (CD8^pos Tresps) in maintaining stable graft function in kidney transplant recipients (KTR) remains largely unclear. The pathogenesis of graft deterioration in case of rejection involves the exhaustive differentiation of both CD8^pos T cell subsets, but the causal mechanisms have not yet been identified.

Methods

In this study, we separately investigated the differentiation of CD8^posTregs/Tresps in 134 stable KTR with no evidence of renal graft rejection, in 41 KTR diagnosed with biopsy-confirmed rejection at enrolment and in 5 patients who were unremarkable at enrolment, but developed rejection within three yea

SUBMITTER: Kalble F 

PROVIDER: S-EPMC11802571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature