Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model.

ABSTRACT:

Introduction

This study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.

Methods

O1_cal6.4b was systemically administered to Wistar rats, and its effects on thermal hyperalgesia and motor coordination were evaluated. Comparative analyses were conducted against O1_cal6.4d, ω-MVIIA, and standard analgesics (morphine, dexamethasone, and diclofenac). Structural differences between O1_cal6.4b and O1_cal6.4d were examined using in silico modeling and molecular dynamics simulations.

Results

Systemic administration of O1_cal6.4b significantly reduced thermal hyperalgesia in a dose-dependent manner without impairing motor coordination.

SUBMITTER: Lopez-Carrillo J 

PROVIDER: S-EPMC11802583 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature