The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01_E.

ABSTRACT: The recently deployed RTS,S/AS01_E malaria vaccine induces a strong antibody response to the circumsporozoite protein (CSP) on the surface of the Plasmodium falciparum sporozoite which is associated with protection. The anti-CSP antibody titre falls rapidly after primary vaccination, associated with a decline in efficacy, but the antibody titre and the protective response can be partially restored by a booster dose of vaccine, but this response is also transitory. In many malaria- endemic areas of Africa, children are at risk of malaria, including severe malaria, until they are five years of age or older and to sustain protection from malaria for this period by vaccination with RTS,S/AS01_E, repeated booster doses of vaccine may be required. However, there is little inf

SUBMITTER: Ali MS 

PROVIDER: S-EPMC11802723 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature