Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator.

ABSTRACT: 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1 H-pyrazol-4-yl)isoxazole (CMPI) is a nicotinic acetylcholine receptor (nAChRs), one of the most subtype-selective a positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs). CMPI that preferentially potentiates the (α4)3(β2)2 nAChR, the major nAChR subtype in the cortex and as such carries potential experimental and therapeutic applications. Maximizing delivery of CMPI would enhance its interaction with brain nAChRs that are associated with the desired therapeutic effects while avoiding interactions with peripheral nAChRs that are associated with undesired side effects is critical to the development of nAChR PAM-based therapeutics. Towards this endeavor, this study aims to explore nanoformulation strategies to max

SUBMITTER: Aly R 

PROVIDER: S-EPMC11802770 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature