How energy determines spatial localisation and copy number of molecules in neurons.

ABSTRACT: In neurons, the quantities of mRNAs and proteins are traditionally assumed to be determined by functional, electrical or genetic factors. Yet, there may also be global, currently unknown computational rules that are valid across different molecular species inside a cell. Surprisingly, our results show that the energy for molecular turnover is a significant cellular expense, en par with spiking cost, and which requires energy-saving strategies. We show that the drive to save energy determines transcript quantities and their location while acting differently on each molecular species depending on the length, longevity and other features of the respective molecule. We combined our own data and experimental reports from five other large-scale mRNA and proteomics screens, comprising more than t

SUBMITTER: Bergmann C 

PROVIDER: S-EPMC11802781 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature