Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock.

ABSTRACT: The phase response curve (PRC) represents the time-dependent changes in circadian rhythm phase following internal or external stimuli. However, this time dependence complicates PRC measurement and quantification owing to its variable shape with changing stimulus intensity. Our previous work demonstrated that resetting a desynchronized circadian clock (singularity response, SR) simplifies the analysis by requiring only amplitude and phase parameters. In this study, we construct a comprehensive model for phase resetting in the mouse circadian clock by converting PRCs into SR parameters. We analyze single-cell PRCs and show that the SR amplitude parameters for different stimulus concentrations follow the Hill equation. Additionally, the model predicts the combined effects of multiple stimuli

SUBMITTER: Masuda K 

PROVIDER: S-EPMC11802799 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature