A lethal disease of the European bison - posthitis is conditionally determined by its genomics.

ABSTRACT: Posthitis is an incurable lethal disease of males of the European bison (Bison bonasus), regarded to be one of the major threats to the survival of the iconic species. Multiple attempts have been undertaken over the last 30 years to identify a source of infection and a primary pathogen. Studies indicated the disease could have a genetic background after tools developed for cattle (Bos taurus) revealed genomic regions that could be associated with its occurrence. In this study, we applied deep coverage targeted sequencing to 74 regions on 10 of the bison's chromosomes (1, 9, 12, 13, 15, 23, 25, 26, 29, and X) in search for species-specific single nucleotide polymorphism (SNP) markers that could help to explain the mechanism of the disease and be used to test for posthitis susceptibility. Th

SUBMITTER: Kunvar S 

PROVIDER: S-EPMC11802879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature