Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins.

ABSTRACT: Salmonella Typhimurium (S. Typhimurium, ST) is a food-borne pathogen that can be transmitted from animals to humans and causes symptoms such as diarrhea, fever, and vomiting. While antibiotics are commonly used to treat clinical infections, the increase in drug resistance has limited their effectiveness. Antivirulence drugs offer a new approach to treating bacterial infections by targeting specific virulence factors without affecting bacterial growth, thus helping to combat infection without exerting selective pressure on bacteria or inducing resistance. Salmonella pathogenicity island 1 (SPI-1), encoding type three secretion system 1 (T3SS-1), serves as a crucial virulence factor for the invasion of ST into host cells, making it an ideal target for screening anti-Salmonella virulence drug

SUBMITTER: Shi Z 

PROVIDER: S-EPMC11802881 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature