MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity.

ABSTRACT: Neuronal mitochondria are diverse across cell types and subcellular compartments in order to meet unique energy demands. While mitochondria are essential for synaptic transmission and synaptic plasticity, the mechanisms regulating mitochondria to support normal synapse function are incompletely understood. The mitochondrial calcium uniporter (MCU) is proposed to couple neuronal activity to mitochondrial ATP production, which would allow neurons to rapidly adapt to changing energy demands. MCU is uniquely enriched in hippocampal CA2 distal dendrites compared to proximal dendrites, however, the functional significance of this layer-specific enrichment is not clear. Synapses onto CA2 distal dendrites readily express plasticity, unlike the plasticity-resistant synapses onto CA2 proximal dendri

SUBMITTER: Pannoni KE 

PROVIDER: S-EPMC11802895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature