Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury.

ABSTRACT: The world's concern about smoking hazards, chronic obstructive pulmonary disease (COPD) and lung cancer was the motivation to investigate plants as a source of new drugs with lung protective effect. The phytochemical profile of Vitis vinifera L. var. King Ruby leaves methanol extract (VLME) was tentatively recognized by liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS). Fifty-two and forty-seven compounds were identified by negative and positive ESI modes, respectively. Taraxerol (1), β-sitosterol (2), daucosterol (3), quercetin-3-O-β-D-glucuronoide-6″-methyl ester (4) and isoquercetin (5) were isolated from VLME. The sulforhodamine B (SRB) assay of the different fractions against A-549 cell line revealed that the methylene chloride fraction (MCF) had t

SUBMITTER: Ahmedy GS 

PROVIDER: S-EPMC11802910 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature