Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration.

ABSTRACT: Cells are thought to adopt mechanistically distinct migration modes depending on cell-type and environmental factors. These modes are assumed to be driven by mutually exclusive actin cytoskeletal organizations, which are either lamellar (flat, branched network) or cortical (crosslinked to the plasma membrane). Here we exploit Drosophila macrophage (hemocyte) developmental dispersal to reveal that these cells maintain both a lamellar actin network at their cell front and a cortical actin network at the rear. Loss of classical actin cortex regulators, such as Moesin, perturb hemocyte morphology and cell migration. Furthermore, cortical and lamellipodial actin networks are interregulated. Upon phosphorylation and binding to the plasma membrane, Moesin is advected to the rear by lamellar actin

SUBMITTER: Sanchez-Sanchez BJ 

PROVIDER: S-EPMC11802916 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature