Mapping genomic regions affecting sensitivity to bovine respiratory disease on chromosome X using selective DNA pooling.

ABSTRACT: Bovine respiratory disease is a leading health problem in feedlot cattle. Identification of affecting genes is essential for selection for decrease sensitivity. Chromosome X is a special attractive target for gene mapping in light of reports on both sexual dimorphism in immunity and higher susceptibility of males to this disease. However, diagnosis is challenging and clinical signs often go undetected. Kosher scoring of lung adhesions was used as a cost-effective proxy diagnosis. Selective DNA pooling was applied for cost-effective mapping of regions associated with sensitivity to the disease on chromosome X in Israeli Holstein male calves. A total of 9 regions were found, more than twice of any of the autosomes. All regions overlapped or were very close to previously reported regions. Bio

SUBMITTER: Lipkin E 

PROVIDER: S-EPMC11802930 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature