Rnf20 inhibition enhances immunotherapy by improving regulatory T cell generation.

ABSTRACT:

Background

Allergic disorders are common all over the world. The pathogenesis of allergy is unclear. Therapies for allergic disorders require improvement. Endoplasmic reticulum (ER) stress is one of the factors influencing immune response. The purpose of this study is to improve the effectiveness of immunotherapy for experimental respiratory allergy by targeting the ER stress signal pathway.

Methods

Committed CD4⁺ T cells were isolated from blood samples collected from patients with allergic rhinitis (AR) and TCR ovalbumin transgenic mice. The effects of TCR engagement and 3-methyl-4-nitrophenol (MNP) on inducing ER stress in committed CD4⁺ T cells were evaluated.

Results

ER stress was detected in antigen-specific CD4⁺ T cells (sCD4

SUBMITTER: Luo X 

PROVIDER: S-EPMC11802951 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature