3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome.

ABSTRACT: Human space travel and exploration are of interest to both the industrial and scientific community. However, there are many adverse effects of spaceflight on human physiology. In particular, there is a lack of understanding of the extent to which microgravity affects the immune system. T cells, key players of the adaptive immune system and long-term immunity, are present not only in blood circulation but also reside within the tissue. As of yet, studies investigating the effects of microgravity on T cells are limited to peripheral blood or traditional 2D cell culture that recapitulates circulating blood. To better mimic interstitial tissue, 3D cell culture has been well established for physiologically and pathologically relevant models. In this work, we utilize 2D cell culture and 3D colla

SUBMITTER: ElGindi M 

PROVIDER: S-EPMC11803002 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature