Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing.

ABSTRACT: The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11803221 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature