The appearance of scalp high-frequency oscillations is associated with poor seizure control in pediatric epilepsy patients.

ABSTRACT:

Objective

Epilepsy treatment with anti-seizure medications (ASMs) is based on careful assessment of the balance between the likelihood of further seizures and the risk of side effects of treatment. However, there is currently no established biomarker to ascertain seizure control status with ASMs. High-frequency oscillations (HFOs), transient bursts of EEG activity with frequencies beyond 80 Hz, are a new and promising noninvasive epilepsy biomarker. We compared the risk of scalp HFO appearance between pediatric patients with good and poor seizure control by treatment with ASMs.

Methods

A total of 72 epilepsy patients (aged 0-18 years, 39 males) with good and poor seizure control with ASMs participated in this study. We applied a validated automated detector to determine HFO

SUBMITTER: Maeda K 

PROVIDER: S-EPMC11803266 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature