Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome-wide association studies.

ABSTRACT:

Objectives

While metabolic imbalances have been observed in individuals with epilepsy, the direct involvement of specific metabolites in the development of the condition remains underexplored. A comprehensive analysis of the causality between cerebrospinal fluid metabolites (CSF) and epilepsy is pivotal in discovering innovative therapeutic interventions and prophylactic approaches.

Methods

Summary data from genome-wide association studies (GWAS) of CSF metabolites and epilepsy subtypes were obtained separately. A total of 338 CSF metabolites were investigated as exposures, and 11 epilepsy phenotypes were examined as the outcomes. A two sample Mendelian randomization (MR) approach was utilized to explore the causal influence of these metabolites on epilepsy. Causality was pr

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11803291 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature