Expanding the chemical space for antiviral discovery: the potential of twistenediones.

ABSTRACT: Despite significant progress in drug discovery, there remains an urgent need to identify new structures capable of targeting drug-resistant diseases, as well as novel pathogens, to address the growing challenges in global health. This work highlights the underexplored potential of twistane-like structures as promising candidates for drug development, particularly as antiviral agents. We provide the first comprehensive study of their antiviral activity, in particular against SARS-CoV-2. We report the synthesis of a family of chiral indolyl-twistenediones, with the separation and characterization of both enantiomers via chiral semipreparative HPLC. The absolute configurations were determined using experimental and theoretical ECD techniques, supported by DFT calculations. A detailed b

SUBMITTER: Jaafar A 

PROVIDER: S-EPMC11803301 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature