Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres.

ABSTRACT: Ischemic stroke, resulting from the obstruction of blood flow to the brain, remains a leading cause of morbidity and mortality worldwide. Traditional imaging modalities, such as magnetic resonance imaging and computed tomography, while effective for identifying stroke locations, are often limited in their ability to detect early pathological changes due to constraints in spatial resolution and sensitivity. This study introduces a novel dual-modal imaging approach that employs indocyanine green-doped porous poly (lactic-co-glycolic acid) (PLGA) microspheres (ICG-pPLGA MPs) for super-resolution ultrasound and near-infrared II (NIR-II) fluorescence imaging of ischemic stroke. The porous structure of ICG-pPLGA MPs enhances their stability, prolongs their circulation time, and improves ultrasou

SUBMITTER: Li Z 

PROVIDER: S-EPMC11803314 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature