The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade.

ABSTRACT:

Significance

Our study reveals UBA1 as a predictive biomarker for clinical outcomes in ICB cohorts, mediating cancer immune evasion and ICB resistance. We further highlight JAK1 stabilization as a key mechanism of UBA1 inhibition and nominate the UBA1-STUB1 axis as an immuno-oncology therapeutic target to improve the efficacy of ICB.

SUBMITTER: Bao Y 

PROVIDER: S-EPMC11803397 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature