Ferula communis leaf extract: antioxidant capacity, UHPLC-MS/MS analysis, and in vivo and in silico toxicity investigations.

ABSTRACT:

Introduction

Ferula communis has demonstrated an abundance of pharmacological and antioxidative qualities.

Methods

This study investigates the antioxidant activity of F. communis leaf aqueous extract, total polyphenol and flavonoid concentrations, and ultra-high-performance liquid chromatography (UHPLC) composition and then evaluates the toxicity of the plant's leaves in vitro and in silico. The major compound of the studied extract, namely, p-hydroxybenzoic acid, was chosen for a molecular docking technique to discover the inhibition mechanism toward antioxidant proteins. In addition, a detailed molecular dynamics simulation was carried out to examine the thermodynamic stability of the produced intermolecular interactions. The antioxidant capacit

SUBMITTER: Ed-Dahmani I 

PROVIDER: S-EPMC11803407 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature