Cognitive function is mediated by deficit accumulation in older, long-term breast cancer survivors.

ABSTRACT:

Purpose

This study aims to examine whether cognitive function in older, long-term breast cancer survivors is both a direct effect of cancer and cancer treatments and an indirect effect mediated by deficit accumulation.

Patients and methods

Female breast cancer survivors who had been diagnosed and treated at age 60 or older and were 5-15-year survivors (N = 220) and age- and education-matched non-cancer controls (N = 123) were assessed at enrollment and at 8-, 16-, and 24-month follow-ups with standard neuropsychological tests and the comprehensive geriatric assessment which was used to calculate the deficit accumulation frailty index (DAFI). Blood or saliva samples for APOE genotyping were collected at enrollment. Participants were purposely recruited so that approximately 5

SUBMITTER: Ahles TA 

PROVIDER: S-EPMC11803569 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature