A Performance-Based Adaptation Index for Automated Insulin Delivery Systems.

ABSTRACT:

Background

Automated insulin delivery (AID) algorithms can benefit from tuning of their aggressiveness to meet individual needs, as insulin requirements vary among and within users. We introduce the Performance-Based Adaptation Index (PAI), a tool designed to enable automatic adjustment of an AID system aggressiveness based on continuous glucose monitoring (CGM) metrics.

Methods

PAI integrates two CGM-based metrics-one for hypoglycemia and another for hyperglycemia exposure-over a previous time window into a single index (αθ). We propose two methods to compute αθ: one based on time in range (TIR, 70-180 mg/dL), and the other on glycemic risk indices. Using αθ, we developed a multiplicative strategy to adjust the AID system's aggressiveness, accounting for situations where αθ

SUBMITTER: Diaz C JL 

PROVIDER: S-EPMC11803600 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature